Lung Density Analysis - Functional

Imbio

Lung Density Analysis™ applies big data analysis to paired inspiratory / expiratory chest CT studies to provide visualization and quantification of lung regions with abnormal tissue density. Functional LDA is an automated image analysis providing a mapping of normal lung, air-trapping and areas of persistent low density (< -950 HU, which may be indicative of emphysema in a combined image to help visualize the components of COPD. LDA provides a full 3D DICOM series with density overlays and a quantitative report of density categories by lung region.

Product specifications

Information source: Vendor
Last updated: Nov. 25, 2021

General
Product name	Lung Density Analysis - Functional
Company	Imbio
Subspeciality	Chest
Modality	CT
Disease targeted	COPD, emphysema, asthma, BOS
Key-features	Lung density quantification, abnormal lung region mapping, report generation
Suggested use	Before: stratifying reading process (non, single, double read), adapting worklist order, flagging acute findings During: perception aid (prompting all abnormalities/results/heatmaps), interactive decision support (shows abnormalities/results only on demand), report suggestion After: diagnosis verification Without interference of a radiologist: AI-only diagnosis
Data characteristics
Population	COPD patients, cases of suspected BOS or asthma
Input	HRCT
Input format	DICOM
Output	Report in PDF or DICOM, overlays
Output format	DICOM, PDF, CSV
Technology
Integration	Integration in standard reading environment (PACS), Integration via AI marketplace or distribution platform, Stand-alone third party application, Stand-alone webbased
Deployment	Locally virtualized (virtual machine, docker), Cloud-based
Trigger for analysis	Automatically, right after the image acquisition, On demand, triggered by a user through e.g. a button click, image upload, etc.
Processing time	> 10 minutes
Certification
CE	Certified, Class IIa , MDD
FDA	510(k) cleared, Class II
Market presence
On market since	2015
Distribution channels	Nuance PIN, Eureka Clinical AI, syngo.via, Wellbeing Software, Aidoc aiOS
Countries present (clinical, non-research use)	>20
Paying clinical customers (institutes)	>20
Research/test users (institutes)	>20
Pricing
Pricing model	Pay-per-use, Subscription
Based on	Number of installations, Number of analyses
Evidence
Peer reviewed papers on performance
Non-peer reviewed papers on performance
Other relevant papers	Quantitative Emphysema on Low-Dose CT Imaging of the Chest and Risk of Lung Cancer and Airflow Obstruction: An Analysis of the National Lung Screening Trial (read)