Bone microarchitecture 3D


Quibim has developed this suite to characterize the trabecular bone microarchitecture based on the analysis of 3D post-processed MRI or CT images. The solution provides bone volume percentage, trabecular thickness, separation and irregularity analysis with fractals, and also combines these biomarkers in a single score, the quality of trabecular structure (QTS) score. The suite has been specifically designed to analyze the trabecular bone of distal regions and vertebrae and it helps identify initial deterioration in patients and follow them up. Analyzing the bone microarchitecture provides additional information to densitometry and supports the assessment of bone diseases such as osteoporosis, joints deterioration and fractures.
Product specifications Information source: Vendor
Last updated: Feb. 11, 2022
Product name Bone microarchitecture 3D
Company Quibim
Subspeciality MSK
Modality CT, MR
Disease targeted Osteoporosis Osteopenia, Multiple myeloma, Osteoarthritis, Joints deterioration, Fractures
Key-features Volume percentage, trabecular thickness, separation and fractal dimensions, and the Quality of a Trabecular Structure (QTS) Score
Suggested use During: perception aid (prompting all abnormalities/results/heatmaps), interactive decision support (shows abnormalities/results only on demand), Need to draw ROI
Data characteristics
Population Patients with bone degenerative diseases
Input MR acquisition protrocol: 3D T1 Gradient Echo CT acquisition protrocol: High Resolution CT. Tranverse
Input format
Output One page structured report: 3D reconstruction of the bone, table of biomarkers, QTS score
Output format DICOM Secondary Capture / PDF
Integration Integration in standard reading environment (PACS), Integration via AI marketplace or distribution platform, Stand-alone third party application, Stand-alone webbased
Deployment Locally on dedicated hardware, Locally virtualized (virtual machine, docker), Cloud-based, Hybrid solution
Trigger for analysis Automatically after drawing ROI
Processing time > 10 minutes
Certified, Class IIa , MDD
No or not yet
Market presence
On market since 01-2019
Distribution channels Alma HEALTH PLATFORM
Countries present (clinical, non-research use) 3
Paying clinical customers (institutes) <5
Research/test users (institutes) <5
Pricing model License
Based on Number of installations, Number of analyses
Peer reviewed papers on performance
Non-peer reviewed papers on performance
Other relevant papers Alberich-Bayarri A, et al. Reproducibility and accuracy in the morphometric and mechanical quantification of trabecular bone from 3 Tesla magnetic resonance images. Radiologia. 2014; 56: 27-34.

Alberich-Bayarri A, et al. Assesment of 2D and 3D fractal dimension measurements of trabecular bone from high-spatial resolution magnetic resonance images at 3 T. Med Phys. 2010; 37: 4930-7.

Alberich-Bayarri A, et al. In vivo trabecular bone morphological and mechanical relationship using high resolution 3 T magnetic resonance imaging. American Journal of Roentgenology. 2008. 1971: 721-726.