Liver Fat & Iron Concentration


Quibim has developed a virtual liver biopsy app that runs an automatic analysis of abdominal MR examinations containing a multi-echo chemical shift (MECSE) sequence with the help of AI. The solution provides a simultaneous quantification of fat and iron concentration with a single-peak approach. The output of the suite includes the parametric maps of fat and iron with voxelwise resolution and a quantitative structured report comparing the liver values of these imaging biomarkers to normative data. This tool supports the early detection, diagnosis, treatment response evaluation and follow-up of a wide range of liver diseases.
Product specifications Information source: Vendor
Last updated: Nov. 19, 2021
Product name Liver Fat & Iron Concentration
Company Quibim
Subspeciality Abdomen
Modality MR
Disease targeted Diffuse liver diseases, Cirrhosis, Fibrosis, Steatohepatitis, Hemochromatosis, Metabolic syndrome, Obesity, Inflammatory activity
Key-features Liver segmentation, Quantification of PDFF and R2*
Suggested use Without interference of a radiologist: AI-only diagnosis
Data characteristics
Population Screening population
Input MRI MECSE Multi-Echo Chemical Shift Encoded
Input format
Output One-page structured report: PDFF and iron concentration parametric map, distribution table, statistics summary, steatosis grade
Output format DICOM Secondary Capture / PDF
Integration Integration in standard reading environment (PACS), Integration via AI marketplace or distribution platform, Stand-alone third party application, Stand-alone webbased
Deployment Locally on dedicated hardware, Locally virtualized (virtual machine, docker), Cloud-based, Hybrid solution
Trigger for analysis Automatically, right after the image acquisition
Processing time 1 - 10 minutes
Certified, Class IIa , MDD
No or not yet
Market presence
On market since 01-2019
Distribution channels Alma HEALTH PLATFORM
Countries present (clinical, non-research use) 4
Paying clinical customers (institutes) 5+
Research/test users (institutes) <5
Pricing model License
Based on Number of installations, Number of analyses
Peer reviewed papers on performance
Non-peer reviewed papers on performance
Other relevant papers França, M., Martí-Bonmatí, L., Porto, G., Silva, S., Guimaräes, S. and Alberich-Bayarri, Á. (2017). Tissue iron quantification in chronic liver diseases using MRI shows a relationship between iron accumulation in liver, spleen, and bone marrow. Clinical Radiology.

França, M., Alberich-Bayarri, Á. and Martí-Bonmatí, L. (2017). Accurate simultaneous quantification of liver steatosis and iron overload in diffuse liver diseases with MRI. Abdominal Radiology, 42(5), pp. 1434-1443.

Martí-Bonmatí, L., Alberich-Bayarri, Á. and Sánchez-González, J. (2012). Overload hepatitides: quanti-qualitative analysis. Abdom. Imaging. 37(2): 180-7.

Erturk, SM., Alberich-Bayarri, Á., Herrmann, KA., Martí-Bonmatí, L. and Ros, PR. (2009). Use of 3.0-T MR imaging for evaluation of the abdomen. Radiographics. 29(6): 1547-63.