Perfusion pharmacokinetics modeling

Quibim

Quibim's Dynamic Contrast Enhanced (DCE) PKM perfusion automatically extracts vascular-based imaging biomarkers to detect changes associated with increased tumor neoangiogenesis activity and aggressiveness. The Pharmacokinetic (PKM) model used in the app helps detect neoplasms and quantifies tumor neoangiogenesis to stage cancer aggressiveness. This suite supports the characterization of tumoral processes in the early detection, diagnosis, treatment response evaluation and follow-up of patients with cancer.

Product specifications

Information source: Vendor
Last updated: Feb. 11, 2022

General
Product name	Perfusion pharmacokinetics modeling
Company	Quibim
Subspeciality	Abdomen
Modality	MR
Disease targeted	Solid tumors, Prostate cancer, Rectal cancer, Endometrial cancer, Liver cancer
Key-features	Ktrans, Fractional volume of extra vascular extracellular space, Suggested use of software (before, during or after study assessment), time constant for gadolinium reflux from the EES back into the vascular system
Suggested use	During: perception aid (prompting all abnormalities/results/heatmaps), interactive decision support (shows abnormalities/results only on demand), Need to draw ROI
Data characteristics
Population	Patients under pharmaceutical treatment for an anomaly or tumor
Input	MRI DSC-MR (Dynamic Susceptibility Contrast)
Input format
Output	One-page structured report: parametric maps, histograms and statistics summary of the rate of gadolinium influx from plasma into the EES (ktrans), time constant for gadolinium reflux (kep) and volume fraction of the EES (ve)
Output format	DICOM Secondary Capture / PDF
Technology
Integration	Integration in standard reading environment (PACS), Integration via AI marketplace or distribution platform, Stand-alone third party application, Stand-alone webbased
Deployment	Locally on dedicated hardware, Locally virtualized (virtual machine, docker), Cloud-based, Hybrid solution
Trigger for analysis	Automatically after drawing ROI
Processing time	> 10 minutes
Certification
CE	Certified, Class IIa , MDD
FDA	No or not yet
Market presence
On market since	01-2019
Distribution channels	Alma HEALTH PLATFORM
Countries present (clinical, non-research use)	10
Paying clinical customers (institutes)	5+
Research/test users (institutes)	15+
Pricing
Pricing model	License
Based on	Number of installations, Number of analyses
Evidence
Peer reviewed papers on performance
Non-peer reviewed papers on performance
Other relevant papers	Martí-Bonmatí L, Ramírez-Fuentes C, Alberich-Bayarri Á, Ruiz-Llorca C. State-of-the-art of bone marrow imaging in multiple myeloma. Curr Opin Oncol. 2015 Nov; 27(6): 540-50. Sanz-Requena R, Prats-Montalbán JM, Martí-Bonmatí L, Alberich-Bayarri Á, García-Martí G, Pérez R, Ferrer A. Automatic individual arterial input functions calculated from PCA outperform manual and population-averaged approaches for the pharmacokinetic modeling of DCE-MR images. J Magn Reson Imaging. 2015 Aug; 42(2): 477-87.