The LEOPARD Challenge

Cross-Organ and Cross-Scanner Adenocarcinoma Segmentation

MONKEY challenge: Detection of inflammation in kidney biopsies

MONKEY (Machine-learning for Optimal detection of iNflammatory cells in KidnEY)

PUMA: Panoptic segmentation of nUclei and tissue in MelanomA

The PUMA Challenge aims to enhance nuclei and tissue segmentation in melanoma histopathology, addressing the need for better prognostic biomarkers to predict treatment responses. Melanoma, a highly aggressive skin cancer, often requires immune checkpoint inhibition therapy, but only half of patients respond. Prognostic biomarkers like tumor infiltrating lymphocytes (TILs) correlate with better therapy responses and lower recurrence rate, but manual TIL scoring is subjective and inconsistent. Current deep learning methods underperform. The PUMA dataset includes annotated primary and metastatic melanoma regions to improve segmentation techniques. The challenge includes two tracks with tasks focused on tissue and nuclei segmentation, encouraging advanced methods to improve predictive accuracy.

REport Generation in pathology using Pan-Asia Giga-pixel WSIs

This project focuses on advancing automated pathology report generation using vision-language foundation models. It addresses the limitations of traditional NLP metrics (e.g., BLEU, METEOR, ROUGE) by emphasizing clinically relevant evaluation. The initiative includes standardized datasets, expert comparisons, and medical-domain-specific metrics to assess model performance. It also explores the integration of generated reports into diagnostic workflows with clinical feedback. To support fairness and generalizability, the challenge dataset comprises ~20,500 cases from six medical centers in Korea, Japan, India, Turkey, and Germany, promoting multicultural and multiethnic medical AI development.