Lingrui Cai
lingrui
- United States of America
- University of Michigan
- Computational medicine and bioinformatics
Statistics
- Member for 1 year, 5 months
- 2 challenge submissions
- 7 algorithms run
Activity Overview
LNQ2023
Challenge UserAccurate lymph node size estimation is critical for staging cancer patients, initial therapeutic management, and in longitudinal scans, assessing response to therapy. Current standard practice for quantifying lymph node size is based on a variety of criteria that use unidirectional or bidirectional measurements on just one or a few nodes, typically on just one axial slice. But humans have hundreds of lymph nodes, any number of which may be enlarged to various degrees due to disease or immune response. While a normal lymph node may be approximately 5mm in diameter, a diseased lymph node may be several cm in diameter. The mediastinum, the anatomical area between the lungs and around the heart, may contain ten or more lymph nodes, often with three or more enlarged greater than 1cm. Accurate segmentation in 3D would provide more information to evaluate lymph node disease.
PUMA: Panoptic segmentation of nUclei and tissue in MelanomA
Challenge UserThe PUMA Challenge aims to enhance nuclei and tissue segmentation in melanoma histopathology, addressing the need for better prognostic biomarkers to predict treatment responses. Melanoma, a highly aggressive skin cancer, often requires immune checkpoint inhibition therapy, but only half of patients respond. Prognostic biomarkers like tumor infiltrating lymphocytes (TILs) correlate with better therapy responses and lower recurrence rate, but manual TIL scoring is subjective and inconsistent. Current deep learning methods underperform. The PUMA dataset includes annotated primary and metastatic melanoma regions to improve segmentation techniques. The challenge includes two tracks with tasks focused on tissue and nuclei segmentation, encouraging advanced methods to improve predictive accuracy.