Mistake in the dataset.json

Mistake in the dataset.json  

  By: Zhack on July 19, 2024, 9:46 p.m.

Hi,

In the given dataset.json file, the channels are both named "CT". This triggers in turn the CTNormalization normalization scheme for PET images in nnUNet, which might be bad. I changed it to "PT", to recover the "ZNormalization" normalization scheme for PET images Keep an eye out for it if you hadn't noticed it before

Regards Zhack

Re: Mistake in the dataset.json  

  By: jdex on July 20, 2024, 10:27 a.m.

Hi Zhack,

That's actually not a mistake. This is set on purpose. If you assume the standardized uptake value (SUV) does what it should and represents standardized physical quantities, a global normalization scheme is a valid assumption. However, one could argue that this assumption does not hold, especially in a multitracer, multicenter setting. So, trying out new approaches might be beneficial. Thanks for bringing that up!

Best Jakob

Re: Mistake in the dataset.json  

  By: Zhack on July 22, 2024, 7:13 a.m.

Dear Jakob, Thanks for the clarification!

This makes sense indeed, and I think both methods do have their pros and cons

My reasoning for preferring ZNorm (no big trade secret ;) is that you may have patient specific variations in SUV values / distribution, linked to their activity between injection and acquisition, glycemia and other physiological specificities.

Best, Zhack